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GERALDO MEDEIROS-NETO, M.D., FACP


Dr. Medeiros-Neto was born in 1936 and graduated from the University of Sao Paulo Medical School in 1959.
After receiving a fellowship in Nuclear Medicine (Hospital das Clinicas) and the James Picker Foundation Clinical and Research Fellowship at the Massachusetts General Hospital, Harvard Medical School, in 1963 and 1964.
Dr. Medeiros-Neto became assistant Professor of Medicine in 1965 at the University of Sao Paulo Medical School.

He received his doctorate in Medicine in 1967 and was appointed Professor of Medicine (University of Sao Paulo School)
in 1973.
Since 1965, Dr. Medeiros-Neto has served as head of Thyroid Laboratory at the University of Sao Paulo Medical School' Hospital das Clinicas. His research has been in the area of endemic goiter and cretinism, thyroid dishormonogenesis, nutritional and growth disorders.

Dr. Medeiros-Neto has published over 210 papers in several national and international journals and authored or
co-authored 10 books on Thyroid Disease and Nutrition Disorders.

He is also editor of "Frontiers in Thyroidology" published by Plenum Press, New York (1986) containing the papers presented at the 9th International Thyroid Congress.
Contributed with chapters to leading text books such as DeGroot's "Endocrinology" and Ingbar & Braverman
"The Thyroid".
Member of key Endocrine and Thyroid Societies in the USA, ASIA, EUROPE and LATIN AMERICA,.
Dr. Medeiros-Neto has received several prizes for this research work including the International LATS award of 1980.

He was one of the founders and served as its first President of the Latin American Thyroid Society in 1974-1978, and was Organizer for the 9th International Thyroid Congress that was held in Sao Paulo (1985). With R. Maciel and A. Halpern edited "Iodine Deficiency Disorders and Congenital Hypothyroidism", Aché, 1986.

He joined in 1985, the Executive Committee of the International Council for Control of Iodine Deficiency Disorders - (ICCIDD).

Was indicated as Professor Adjunct of the University of Miami, Department of Medicine (1986). Admitted as Fellow of the American College of Physicians (1986).

Editor of the book "Obesity, a new Metabolic Frontier" (1987). President of the Brazilian Association for the Study of Obesity (1987) and Chairman of the Board (1989). Member of the Council of the International Association for the Study of Obesity (1987-1990).

Member of the editorial Board of leading medical journals in his specialty such as "The Journal of Clinical Endocrinology and Metabolism", "Journal of Endocrinological Investigation", "Thyroid" and "Arch Bras Endocr and Metab".

Was elected Governor of the American College of Physicians Affiliate Region of Brazil (1991-1995).

President of the V Latin American Thyroid Congress (1991).

Visiting Professor at the University of Miami, Dept. of Medicine in February, 1992-1994.
Elected Member of the Academy of Medicine (Sao Paulo) in June 1992. Elected as Director of the "Academia de Medicina de São Paulo" in August 1993.

Published the book "Inherited disorders of the thyroid system", CRC Press, 1994.
Visiting Professor and Lecturer, University of Chile, Santiago, 1995.

Received the prize "ACADEMIA DE MEDICINA" 1995 and the "Paul Starr Award"(American Thyroid Association) in 1996.
Organizer and chairman of the International Symposium on Thyroid Nodules (1997) and the 4th International Workshop on Resistance to Thyroid Hormone (1999).

Organizer and President of the 9th International Congress on Obesity (9th ICO) held in Sao Paulo, Brazil, 2002.Editor: "Progress in Obesity Research 9 9, 2003".

Research Interests
Iodine deficiency disorders and its consequences.
Naturally occurring goitrogens.
Genetic defects in thyroid metabolism:
Pathophysiology and molecular biological studies.
Resistance to thyroid hormone


Membership in Professional Societies
American Thyroid Association
Endocrine Society
European Thyroid Association
Société Française d'Endocrinologie
Sociedade Chilena de Endocrinologia
Sociedade Brasileira de Endocrinologia e Metabologia
Sociedade Latino-Americana de Tireóide
Associaçao Brasileira para o Estudo da Obesidade
Honorary Member of the "Academia de Medicina", Santiago, Chile


Certification
Brazilian Society of Endocrinology and Metabolism.


Present position
Professor of Endocrinology, Dept. of Medicine, Member of the Board, Dept. Medicine. Chief, Thyroid Unit (Molecular and Cellular Biology Labs), Hosp Clinicas Univ Sao Paulo Medical School



Original Papers Published in Medical Journals (1999-2004)
1- CAMARGO RYA, GROSS JL, SILVEIRO SP, KNOBEL M and MEDEIROS-NETO G. Pathological findings in dyshormonogenetic goiter with defective iodide transport. Endocr Pathol 9(3):225-233, 1999 CREMESP 8870, State of Sao Paulo, Brazil.

2- KOPP P, KARAMANOGLU A, SABACAN L, KOTLAR T, DUPUIS J, CAVALIERE H, SANTOS CLS, JAMESON JL, MEDEIROS-NETO G. Phenocopies for deafness and goiter development in a large inbred Brazilian kindred with Pendred's syndrome associated with a novel mutation in the PDS gene. J Clin Endocrinol Metab 84(3):336-341, 1999

3- TOMIMORI EK, CAMARGO RYA, BISI H, MEDEIROS-NETO G. Combined ultrasonographic and cytological studies in the diagnosis of thyroid nodules. Biochimie 81:447-452, 1999

4- KNOBEL M, UMEZAWA E, CARDIA MS, MARTINS MJ, CORREA MLC, GIANELLA-NETO D AND MEDEIROS-NETO G. Elevated anti-Galactosyl antibody titers in endemic goiter. Thyroid 9(5):493-498, 1999

5- NOGUEIRA CR, NGUYEN LQ, COELHO-NETO JR, ARSEVEN OK, JAMESON JL, KOPP P, MEDEIROS-NETO G. Structural analysis of the TSH-receptor in four patients with congenital hypothyroidism due to thyroid hypoplasia. Thyroid 9(6):523-529, 1999

6- NOGUEIRA CR, MEDEIROS-NETO G, SABACAN L, JAMESON LJ, KOPP P. Combined pituitary hormone deficiency (CPHD) in an inbred Brazilian kindred associated with a mutation in the PROP-1 gene. Molec Genet Metabol 67:58-61, 1999

7- SANTOS CLS, BIKKER H, REGO KGM, NASCIMENTO AC, TAMBASCIA M, DEVIJLDER JJM, MEDEIROS-NETO G. A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect. Clin Endocrinol 51:165-172, 1999

8- VAN DE GRAAF SAR, RIS-STALPERS C, VEENBOER GJM, CAMMENGA M, SANTOS CLS, TARGOVNIK HM, DE VIJLDER JMJ, MEDEIROS-NETO G. A premature stopcodon in thyroglobulin mRNA results in familial goiter and moderate hypothyroidism. J Clin Endocrinol Metab 84(7):2537-2542, 1999

9- NOGUEIRA CR, KOPP P, ARSEVEN OK, SANTOS CLS, JAMESON JL, MEDEIROS-NETO G. Thyrotropin (TSH) receptor mutations in hyperfunctioning thyroid adenomas from Brazil. Thyroid 9(11):1063-1068, 1999

10- BARCA MF, KNOBEL M, TOMIMORI E, CARDIA MS, MEDEIROS-NETO G. Prevalence and characteristics of postpartum thyroid dysfunction in São Paulo, Brazil. Clin Endocrinol 53:21-31, 2000

11- MEDEIROS-NETO G. Thyroid in the third millenium. Quo vadis? Thyroid 10(3):227, 2000

12- MEDEIROS-NETO G. The salt iodization program in Brazil: A medical and political conundrum. IDD News Letter, 16(2):31-32, 2000

13- LIMA N, CAVALIERE H, KNOBEL M, HALPERN A, MEDEIROS-NETO G. Decreased androgen levels in massively obese men is associated with impaired function of the gonadostat. Int J Obesity 24(12):1433-1437, 2000

14- PEDRINOLA F, RUBIO I, SANTOS CLS & MEDEIROS-NETO G. Overexpression of Epidermal Growth Factor (EGF) and Epidermal Growth Fator-Receptor (EGF-R) messenger RNAs in Dyshormonogenetic Goiters. Thyroid 11:15-20, 2001

15- TARGOVNIK HM, RIVOLTA CM, MENDIVE FM, MOYA CM, VONO J & MEDEIROS-NETO G. Congenital goiter with hypothyroidism caused by a 5'splice site mutation in the thyroglobulin gene. Thyroid 11(7): 683-688, 2001.

16- GONZALEZ TREVINO, KARAMANOGLU ARSEVEN, CJ CEBALLOS, VI VIVES, RC RAMIREZ, G MEDEIROS-NETO, P KOPP. Clinical and molecular analysis of three Mexican families with Pendred's syndrome. Eur J Endocrinol 144:585-593, 2001.

17- CAVALIERE H, FLORIANO I, MEDEIROS-NETO G. Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid). Int J Obesity 25:1095-1099, 2001.

18- CONGDON T, NGUYEN LQ, NOGUEIRA CR, HABIBY R, MEDEIROS-NETO G, KOPP P. A novel mutation (Q40P) in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child. J Clin Endocrinol Metab. 86:3962-3967, 2001.

19- MEDEIROS-NETO G. Searching for Iodine Deficiency Disorders (IDD) in schoolchildren from Brazil: The Thyromobil project. Thyroid 11(7):661-663, 2001.

20- CAMARGO R, LIMBERT E, GILLAM M, HENRIQUES MM, FERNANDES C, CATARINO AL, SOARES J, ALVES VAF, KOPP P & MEDEIROS-NETO G. Aggressive metastatic follicular thyroid carcinoma with anaplastic transformation arising from a long standing goiter in a patient with Pendred's syndrome. Thyroid 11(10):981-988, 2001.

21- NASCIMENTO MCPA, BISI H, ALVES VAF, LONGATTO-FILHO A, KANAMURA CT & MEDEIROS-NETO G. Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas. Endocr Pathol 12(3):275-279, 2001.

22- ROSSI A, TOMIMORI E, CAMARGO R, MEDEIROS-NETO G. Determination of thyroid volume by ultrasound in healthy Brazilian school children. J Clin Ultrasound 30:226-231, 2002

23- LIMA N, CAVALIERE H, TOMIMORI E, KNOBEL M & MEDEIROS-NETO G. Prognostic value of serial serum thyroglobulin determinations after total thyroidectomy for differentiated thyroid cancer. J Endocrinol Invest 25:110-115, 2002

24- KNOBEL M & MEDEIROS-NETO G. An Outline of Inherited Disorders of the Thyroid Hormone Generating System. Thyroid 13(8):771-801, 2003

25- NASCIMENTO AC, GUEDES DR, SANTOS CS, RUBIO IGS, KNOBEL M & MEDEIROS-NETO G. Thyroperoxidase (TPO) gene mutations in congenital goitrous hypothyroidism with total (TIOD) and partial (PIOD) iodide organification defect. Thyroid 13(12):1145-1151, 2003

26- SILVA MNC, RUBIÓ IGS, BUCHPIGUEL C, TOMIMORI E, CAMARGO E, MEDEIROS-NETO G. Administration of a single dose of recombinant human thyrotropin enhances the efficacy of the radioiodine treatment of large compressive multinodular goiters. Clinical Endocrinol 60(3):300-308, 2004

27- GUTNISKY VJ, MOYA CM, RIVOLTA CM, DOMENÉ S, VARELA V, TONIOLO JV, MEDEIROS-NETO G & TARGOVNIK HM. Two distinct compound heterozygous constellation (R277X / IVS34-1G>C and R277X / R1511X) in the thyroglobulin gene in affected individuals of a Brazilian kindred with congenital goiter and defective thyroglobulin synthesis. J Clin Endocrinol Metab __:___-___, 2004 (in press)

28- MENDIVE FM, GONZÁLEZ-SARMIENTO R, MEDEIROS-NETO G, TARGOVNIK HM. Nonsense-mediated alternative splicing of the human thyroglobulin gene. J Molec Endocrinol __:__-__, 2004 (in press)

29- CARDIA MS, LIMA N, KNOBEL M, MEDEIROS-NETO G. Evaluation of a coated tube assay for anti-TSH receptor antibodies in patients with Graves' disease and other thyroid disorders. Thyroid __:__-__, 2004 (in press)

30- PRETELL EA, DELANGE F, HOSTALEK U, CORIGLIANO S, BARREDA L, HIGA AM, ALTSCHULER N, BARRAGAN D, CEVALLOS JL, GONZALES O, JARA JA, MEDEIROS-NETO G, MONTES JA, MUZZO S, PACHECO VM, CORDERO L. Iodine Nutrition Improves in Latin America. Thyroid __:__-__, 2004 (in press)